The G2019S LRRK2 mutation is uncommon amongst Greek patients with sporadic Parkinson's disease
Identifieur interne : 000F41 ( Main/Exploration ); précédent : 000F40; suivant : 000F42The G2019S LRRK2 mutation is uncommon amongst Greek patients with sporadic Parkinson's disease
Auteurs : K. Kalinderi [Grèce] ; L. Fidani [Grèce] ; S. Bostantjopoulou [Grèce] ; Z. Katsarou [Grèce] ; A. Kotsis [Grèce]Source :
- European Journal of Neurology [ 1351-5101 ] ; 2007-10.
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Abstract
Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting approximately 2% of the population >60 years of age. Although, the etiology of PD is still unknown, the genetic background of the disease has been documented. Recently, a mutation in the LRRK2 gene, G2019S, was associated with 3–41% and 1–2% of familial and sporadic PD, respectively suggesting a pivotal role of LRRK2 in PD. In this report, we examine the association of the G2019S mutation with sporadic late‐onset PD, in an independent cohort of Greek patients and controls.
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DOI: 10.1111/j.1468-1331.2007.01867.x
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Although, the etiology of PD is still unknown, the genetic background of the disease has been documented. Recently, a mutation in the LRRK2 gene, G2019S, was associated with 3–41% and 1–2% of familial and sporadic PD, respectively suggesting a pivotal role of LRRK2 in PD. In this report, we examine the association of the G2019S mutation with sporadic late‐onset PD, in an independent cohort of Greek patients and controls.</div></front></TEI><affiliations><list><country><li>Grèce</li></country></list><tree><country name="Grèce"><noRegion><name sortKey="Kalinderi, K" sort="Kalinderi, K" uniqKey="Kalinderi K" first="K." last="Kalinderi">K. Kalinderi</name></noRegion><name sortKey="Bostantjopoulou, S" sort="Bostantjopoulou, S" uniqKey="Bostantjopoulou S" first="S." last="Bostantjopoulou">S. Bostantjopoulou</name><name sortKey="Fidani, L" sort="Fidani, L" uniqKey="Fidani L" first="L." last="Fidani">L. Fidani</name><name sortKey="Katsarou, Z" sort="Katsarou, Z" uniqKey="Katsarou Z" first="Z." last="Katsarou">Z. Katsarou</name><name sortKey="Kotsis, A" sort="Kotsis, A" uniqKey="Kotsis A" first="A." last="Kotsis">A. Kotsis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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